Bee therapy for arthritis and osteoarthritis has gained increasing attention due to the anti-inflammatory, analgesic, and immunomodulatory effects of bee venom (apitoxin). Scientific studies have shown its potential to modulate inflammatory pathways, reduce joint pain, and improve function in patients with chronic joint diseases. This article reviews the main benefits of apitoxin, its biological mechanisms, and the scientific evidence supporting its therapeutic use in arthritis and osteoarthritis.